Intestinal macrophages and dendritic cells: what's the difference?

被引：209

作者：

Cerovic, Vuk ^{[1
]}

Bain, Calum C. ^{[1
]}

Mowat, Allan M. ^{[1
]}

Milling, Simon W. F. ^{[1
]}

机构：

[1] Univ Glasgow, Ctr Innmunobiol, Inst Infect Immun & Inflammat, Glasgow G12 8TA, Lanark, Scotland

来源：

TRENDS IN IMMUNOLOGY | 2014年 / 35卷 / 06期

基金：

英国医学研究理事会;

关键词：

intestine; dendritic cells; macrophages; mouse; REGULATORY T-CELLS; LAMINA PROPRIA; INFLAMMATORY MONOCYTES; LY6C(HI) MONOCYTES; YOLK-SAC; GUT; LYMPH; EXPRESSION; RESPONSES; MUCOSAL;

D O I：

10.1016/j.it.2014.04.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Mononuclear phagocytes (MPs) in the murine intestine, comprising dendritic cells (DCs) and macrophages (M phi s), perform disparate yet complementary immunological functions. Functional analyses of these distinct MP subsets have been complicated by the substantial overlap in their surface phenotypes. Here, we review recent findings that have enabled more accurate definition of these MP subsets. We discuss these recent advances in the context of the current understanding of the functions of DCs and M phi s in the maintenance of intestinal homeostasis, and how their functions may alter when homeostasis is disrupted.

引用

收藏

页码：270 / 277

页数：8

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