A transcription map of the major histocompatibility complex (MHC) class I region

被引：42

作者：

Gruen, JR

Nalabolu, SR

Chu, TW

Bowlus, C

Fan, WF

Goei, VL

Wei, H

Sivakamasundari, R

Liu, YC

Xu, HX

Parimoo, S

Nallur, G

Ajioka, R

Shukla, H

BrayWard, P

Pan, J

Weissman, SM

机构：

[1] YALE UNIV, SCH MED, DEPT GENET, NEW HAVEN, CT 06510 USA

[2] YALE UNIV, SCH MED, DEPT INTERNAL MED, NEW HAVEN, CT 06510 USA

[3] UNIV UTAH, SCH MED, DIV HEMATOL ONCOL, SALT LAKE CITY, UT 84112 USA

[4] LAWRENCE LIVERMORE NATL LAB, CTR HUMAN GENOME, LIVERMORE, CA 94551 USA

[5] RW JOHNSON PHARMACEUT RES INST, SKIN BIOL CTR, RARITAN, NJ 08869 USA

[6] BIOGEN INC, CAMBRIDGE, MA 02142 USA

[7] SMITHKLINE BEECHAM PHARMACEUT, KING OF PRUSSIA, PA 19406 USA

来源：

GENOMICS | 1996年 / 36卷 / 01期

关键词：

D O I：

10.1006/geno.1996.0427

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have applied cDNA hybridization selection to nine YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the human major histocompatibility complex (MHC). In addition to Class I genes and pseudogenes, we describe over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these are a group of genes encoding proteins showing homology to the carboxyl-terminal sequences of butyrophilin and an additional group of zinc finger genes. We also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than has been appreciated. (C) 1996 Academic Press, Inc.

引用

页码：70 / 85

页数：16

共 103 条

[1] CLONING THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX IN YACS [J].