New DNA minor-groove binding molecules with high sequence-selectivities and binding affinities

被引：14

作者：

Gong, B

Yan, YF

机构：

[1] Department of Chemistry, University of Toledo, Toledo

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 240卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.7697

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New DNA minor-groove binding molecules with high binding affinities and sequence-selectivities are described. The effects of structural changes in ligands with a three-ring backbone on their DNA-binding properties have been studied. Of a pool of eight potential ligands, two showed binding affinities and sequence-selectivities rivaling distamycin. The two best ligands share a common structural motif that involves a para-di-substituted benzene ring flanked by two meta-di-substituted benzene rings. (C) 1997 Academic Press.

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页码：557 / 560

页数：4

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