Contribution to the kinetics and amplitude of the electroretinogram b-wave by third-order retinal neurons in the rabbit retina

被引：88

作者：

Dong, CJ ^{[1
]}

Hare, WA ^{[1
]}

机构：

[1] RD 2C Allergan Inc, Dept Biol Sci, Irvine, CA 92612 USA

来源：

VISION RESEARCH | 2000年 / 40卷 / 06期

关键词：

ERG; a-wave; b-wave; inner retina; rabbit;

D O I：

10.1016/S0042-6989(99)00203-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ERG b-wave is widely believed to reflect mainly light-induced activity of on-center bipolar cells and Muller cells. Third-order retinal neurons are thought to contribute negligibly to generation of the b-wave. Here we show that pharmacological agents which affect predominantly third-order neurons alter significantly both the kinetics and amplitude of the b-wave. Our results support the notion that changes in the amplitude and kinetics of right-induced membrane depolarization in third-order neurons produce similar changes in the amplitude and kinetics of the b-wave. We conclude that activity in third-order neurons makes a significant contribution to b-wave generation. Our results also provide evidence that spiking activity of third-order neurons truncates the a-wave by accelerating the onset of the b-wave. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：579 / 589

页数：11

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