The gut microbiota influences blood-brain barrier permeability in mice

被引：1756

作者：

Braniste, Viorica ^{[1
]}

Al-Asmakh, Maha ^{[1
]}

Kowal, Czeslawa ^{[2
]}

Anuar, Farhana ^{[1
]}

Abbaspour, Afrouz ^{[1
]}

Toth, Miklos ^{[3
]}

Korecka, Agata ^{[1
]}

Bakocevic, Nadja ^{[4
]}

Ng, Lai Guan ^{[4
]}

Kundu, Parag ^{[5
]}

Gulyas, Balazs ^{[3
,5
]}

Halldin, Christer ^{[3
,5
]}

Hultenby, Kjell ^{[6
]}

Nilsson, Harriet ^{[7
,8
]}

Hebert, Hans ^{[7
,8
]}

Volpe, Bruce T. ^{[9
]}

Diamond, Betty ^{[2
]}

Pettersson, Sven ^{[1
,5
,10
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden

[2] North Shore LIJ Hlth Syst, Feinstein Inst Med Res, Ctr Autoimmune & Musculoskeletal Dis, Manhasset, NY 11030 USA

[3] Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, S-17177 Stockholm, Sweden

[4] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore 138648, Singapore

[5] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 637551, Singapore

[6] Karolinska Inst, Dept Lab Med, S-14186 Stockholm, Sweden

[7] Karolinska Inst, Dept Biosci & Nutr, SE-14157 Huddinge, Sweden

[8] KTH Royal Inst Technol, Sch Technol & Hlth, SE-14157 Huddinge, Sweden

[9] North Shore LIJ Hlth Syst, Feinstein Inst forMed Res, Lab Funct Neuroanat, Manhasset, NY 11030 USA

[10] Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn SCFI SF, Singapore 637551, Singapore

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 263期

关键词：

CHAIN FATTY-ACIDS; TIGHT JUNCTION PROTEINS; NECROSIS-FACTOR-ALPHA; SODIUM-BUTYRATE; INTEGRITY; IMMUNOLOCALIZATION; NEUROGENESIS; METABOLISM; INHIBITOR; PERICYTES;

D O I：

10.1126/scitranslmed.3009759

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts as a gatekeeper to control the passage and exchange of molecules and nutrients between the circulatory system and the brain parenchyma. The BBB also ensures homeostasis of the central nervous system (CNS). We report that germ-free mice, beginning with intrauterine life, displayed increased BBB permeability compared to pathogen-free mice with a normal gut flora. The increased BBB permeability was maintained in germ-free mice after birth and during adulthood and was associated with reduced expression of the tight junction proteins occludin and claudin-5, which are known to regulate barrier function in endothelial tissues. Exposure of germ-free adult mice to a pathogen-free gut microbiota decreased BBB permeability and up-regulated the expression of tight junction proteins. Our results suggest that gut microbiota-BBB communication is initiated during gestation and propagated throughout life.

引用

页数：11

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