Highly stereoselective molecularly imprinted polymer synthetic receptors for cinchona alkaloids

被引：56

作者：

Matsui, J

Nicholls, IA

Takeuchi, T

机构：

[1] UNIV KALMAR,SCH NAT SCI,S-39129 KALMAR,SWEDEN

[2] HIROSHIMA CITY UNIV,FAC INFORMAT SCI,LAB SYNTHET BIOCHEM,ASAMINAMI KU,HIROSHIMA 73131,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 05期

关键词：

D O I：

10.1016/0957-4166(96)00152-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Molecularly imprinted polymer (MIP) receptors for the cinchona alkaloids (-)-cinchonidine 1 and (+)-cinchonine 2 have been prepared and characterised using the polymers as HPLC chiral stationary phases(CSPs). Stereoseparation factors of up to 31 were obtained. The resolution of the beta-adrenergic blocking agent propranolol 8 and studies with related structures of pharmaceutical significance has permitted conclusions to be drawn regarding the origin of recognition phenomena. Copyright (C) 1996 Elsevier Science

引用

页码：1357 / 1361

页数：5

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[2]

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