Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease

被引：18

作者：

Ohkura, T

Taniguchi, S ^{[1
]}

Yamada, K

Nishio, N

Okamura, T

Yoshida, A

Kamijou, K

Fukata, S

Kuma, K

Inoue, Y

Hisatome, I

Senju, S

Nishimura, Y

Shigemasa, C

机构：

[1] Tottori Univ, Fac Med, Dept Multidisciplinary Internal Med, Div Mol Med & Therapeut, Yonago, Tottori 6838504, Japan

[2] Kumamoto Univ, Grad Sch Med Sci, Dept Ophthalmol & Visual Sci, Kumamoto 8600811, Japan

[3] Kamijou Thyroid Res Inst, Sapporo, Hokkaido 0600042, Japan

[4] Kuma Hosp, Kobe, Hyogo 6500011, Japan

[5] Olympia Eye Hosp, Tokyo 1500001, Japan

[6] Tottori Univ, Fac Med, Sch Life Sci, Yonago, Tottori 6838504, Japan

[7] Kumamoto Univ, Grad Sch Med Sci, Dept Neurosci & Immunol, Div Immunogenet, Kumamoto 8600811, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 321卷 / 02期

关键词：

uveal autoantigen with coiled coil domains and ankyrin repeats; Graves' disease; Graves' ophthalmopathy; autoantigen; ocular myopathy; FRTL5; Vogt-Koyanagi-Harada disease; thyroid-eye shared autoantigen;

D O I：

10.1016/j.bbrc.2004.06.162

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Uveal autoantigen with coiled coil domains and ankyrin repeats (UACA) is an autoantigen in patients with panuveitis such as Vogt-Koyanagi-Harada disease. The prevalence of IgG anti-UACA antibodies in patients with uveitis is significantly higher than healthy controls, suggesting its potential role as an autoantigen. Originally, UACA was cloned from dog thyroid tissue following TSH stimulation. So, we presumed UACA could be a novel autoantigen in autoimmune thyroid diseases. We measured serum anti-UACA antibody titer using ELISA in patients with autoimmune thyroid diseases (Graves' disease, Hashimoto's thyroiditis, subacute thyroiditis, and silent thyroiditis). The prevalence of anti-UACA antibodies in Graves' disease group was significantly higher than that in healthy group (15% vs. 0%). Moreover, the prevalence of anti-UACA antibodies in Graves' ophthalmopathy was significantly higher than that in Graves' patients without ophthalmopathy (29% vs. 11%). Especially, 75% of severe ocular myopathy cases showed high UACA titer. Immunohistochemical analysis revealed that UACA protein is expressed in eye muscles as well as human thyroid follicular cells. Taken together, UACA is a novel candidate for eye muscle autoantigens in thyroid-associated ophthalmopathy. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：432 / 440

页数：9

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