In vitro Ciprofloxacin release from poly(lactide-co-glycolide) microspheres

被引：33

作者：

Martinez, B

Lairion, F

Pena, MB

DiRocco, P

Nacucchio, MC

机构：

[1] Dept. of Pharmaceutical Technology, School of Pharmacy and Biochemistry, University of Buenos Aires Junin 956

来源：

JOURNAL OF MICROENCAPSULATION | 1997年 / 14卷 / 02期

关键词：

poly(lactide-co-glycolide); microsphere; ciprofloxacin; drug release;

D O I：

10.3109/02652049709015329

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Biodegradable microspheres of PLGA (75:25 and 50:50) containing Ciprofloxacin (CIPRO) were prepared by two different procedures based on: (i) solvent-evaporation, and (ii) evaporation-extraction of the organic phase. The encapsulation rates from the different formulations were quite variable, as well the release patterns of the drug from the microspheres. The evaporation-extraction method seems to be more efficient for the CIPRO encapsulation compared with the solvent evaporation method. The 50:50 PLGA composition released the drug faster and showed degradation signs after incubation in aqueous medium in both manufacturing methodologies.

引用

页码：155 / 161

页数：7

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