In vitro Ciprofloxacin release from poly(lactide-co-glycolide) microspheres

被引：33

作者：

Martinez, B

Lairion, F

Pena, MB

DiRocco, P

Nacucchio, MC

机构：

[1] Dept. of Pharmaceutical Technology, School of Pharmacy and Biochemistry, University of Buenos Aires Junin 956

来源：

JOURNAL OF MICROENCAPSULATION | 1997年 / 14卷 / 02期

关键词：

poly(lactide-co-glycolide); microsphere; ciprofloxacin; drug release;

D O I：

10.3109/02652049709015329

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Biodegradable microspheres of PLGA (75:25 and 50:50) containing Ciprofloxacin (CIPRO) were prepared by two different procedures based on: (i) solvent-evaporation, and (ii) evaporation-extraction of the organic phase. The encapsulation rates from the different formulations were quite variable, as well the release patterns of the drug from the microspheres. The evaporation-extraction method seems to be more efficient for the CIPRO encapsulation compared with the solvent evaporation method. The 50:50 PLGA composition released the drug faster and showed degradation signs after incubation in aqueous medium in both manufacturing methodologies.

引用

页码：155 / 161

页数：7

共 20 条

[11]

JULIENNE MC, 1989, P INT S CONTROLLED R, V16, P77

[12]

KITCHELL JP, 1985, METHOD ENZYMOL, V112, P436

[13]

Lu W, 1995, PDA J Pharm Sci Technol, V49, P13

[14]

MCGINITY JW, 1992, 6TH INTERNATIONAL CONFERENCE ON PHARMACEUTICAL TECHNOLOGY, VOLS 1-5, P81

[15]

OKADA H, 1989, P INT S CONTROL REL, V16, P12

[16] MACROPHAGE PHAGOCYTOSIS OF BIODEGRADABLE MICROSPHERES COMPOSED OF L-LACTIC ACID GLYCOLIC ACID HOMOPOLYMERS AND COPOLYMERS [J].

TABATA, Y ;

IKADA, Y .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1988, 22 (10) :837-858

[17] EROSION KINETICS OF HYDROLYTICALLY DEGRADABLE POLYMERS [J].

TAMADA, JA ;

LANGER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :552-556

[18]

THIES C, 1988, MICROSPHERES MED BIO, P53

[19]

WANG HT, 1991, COSMETIC AND PHARMACEUTICAL APPLICATIONS OF POLYMERS, P239

[20] INVITRO ACTIVITY OF BAY-09867, A NEW QUINOLINE DERIVATIVE, COMPARED WITH THOSE OF OTHER ANTI-MICROBIAL AGENTS [J].

WISE, R ;

ANDREWS, JM ;

EDWARDS, LJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1983, 23 (04) :559-564

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