Lyn, a src-like tyrosine kinase

被引:40
作者
Hibbs, ML [1 ]
Dunn, AR [1 ]
机构
[1] ROYAL MELBOURNE HOSP,MELBOURNE TUMOUR BIOL BRANCH,LUDWIG INST CANC RES,MELBOURNE,VIC 3050,AUSTRALIA
关键词
D O I
10.1016/S1357-2725(96)00104-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and Fc epsilon RI. Lyn deficient mice develop autoimmune disease characterised,by autoantibodies in serum and the deposition of immune complexes in the kidney, a pathology reminiscent of systemic lupus erythematosus. Lyn deficient mice also have impaired signalling; involving Fc epsilon RI in mast cells, resulting in defective allergic responses. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:397 / 400
页数:4
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