Hydrophobic polymer-supported scandium catalyst for carbon-carbon bond-forming reactions in water

被引：22

作者：

Iimura, S ^{[1
]}

Manabe, K ^{[1
]}

Kobayashi, S ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON | 2004年 / 60卷 / 35期

基金：

日本学术振兴会;

关键词：

lewis acid; scandium; aldol reaction; 1,4-addition; water;

D O I：

10.1016/j.tet.2004.06.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It has been revealed that a hydrophobic polymer-supported scandium(III) catalyst prepared from sulfonated polystyrene resin is an effective catalyst for carbon-carbon bond-forming reactions such as Mukaiyama aldol reactions in water. According to studies on loading levels of scandium, hydrophobicity of the catalyst is a key for the efficient catalysis. The scandium catalyst was successfully recovered and reused. Several ketones instead of aldehydes were also used as substrates in the aldol reactions. Some 1,4-addition reactions also occurred using the scandium catalyst in water. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7673 / 7678

页数：6

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