Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232

被引：14

作者：

Oh, H ^{[1
]}

Kim, BS ^{[1
]}

Bae, EY ^{[1
]}

Kim, MS ^{[1
]}

Kim, BY ^{[1
]}

Leo, HB ^{[1
]}

Kim, CJ ^{[1
]}

Ahn, JS ^{[1
]}

机构：

[1] KRIBB, Taejon 305600, South Korea

来源：

JOURNAL OF ANTIBIOTICS | 2004年 / 57卷 / 08期

关键词：

D O I：

10.7164/antibiotics.57.528

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, 9) and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.

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页码：528 / 531

页数：4

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