Molecular inflammation: Underpinnings of aging and age-related diseases

被引：885

作者：

Chung, Hae Young ^{[1
,2
]}

Cesari, Matteo ^{[2
]}

Anton, Stephen ^{[2
]}

Marzetti, Emanuele ^{[2
]}

Giovannini, Silvia ^{[2
]}

Seo, Arnold Young ^{[2
]}

Carter, Christy ^{[2
]}

Yu, Byung Pal ^{[3
]}

Leeuwenburgh, Christiaan ^{[2
]}

机构：

[1] Pusan Natl Univ, Res Inst Drug Dev, Longev Sci & Technol Inst, Dept Pharm, Pusan 609735, South Korea

[2] Univ Florida, Genom & Biomarkers Core Inst Aging, Div Biol Aging, Dept Aging & Geriatr Res, Gainesville, FL 21611 USA

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA

来源：

AGEING RESEARCH REVIEWS | 2009年 / 8卷 / 01期

关键词：

Molecular inflammation; Aging; Calorie restriction; Exercise; Cytokines; Oxidative stress; Inflammatory diseases; Age-related diseases; Obesity; Sarcopenia; Dementia; Atherosclerosis; Cancer; Osteoporosis; NF-KAPPA-B; MONOCYTE CHEMOATTRACTANT PROTEIN-1; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; SENSITIVE TRANSCRIPTION FACTORS; OXIDATIVE STRESS; CALORIE RESTRICTION; PHYSICAL-ACTIVITY; SKELETAL-MUSCLE; BODY-COMPOSITION;

D O I：

10.1016/j.arr.2008.07.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent scientific studies have advanced the notion of chronic inflammation as a major risk factor underlying aging and age-related diseases. In this review, low-grade, unresolved, molecular inflammation is described as an underlying mechanism of aging and age-related diseases, which may serve as a bridge between normal aging and age-related pathological processes. Accumulated data strongly suggest that continuous (chronic) upregulation of pro-inflammatory mediators (e.g., TNF-alpha, IL-1 beta, IL-6, COX-2, NOS) are induced during the aging process due to an age-related redox imbalance that activates many pro-inflammatory signaling pathways, including the NF-kappa B signaling pathway. These proinflammatory molecular events are discussed in relation to their role as basic mechanisms underlying aging and age-related diseases. Further, the anti-inflammatory actions of aging-retarding caloric restriction and exercise are reviewed. Thus, the purpose of this review is to describe the molecular roles of age-related physiological functional declines and the accompanying chronic diseases associated with aging. This new view on the role of molecular inflammation as a mechanism of aging and age-related pathogenesis can provide insights into potential interventions that may affect the aging process and reduce age-related diseases, thereby promoting healthy longevity. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：18 / 30

页数：13

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