Microcapsule enabled multicatalyst system

被引：108

作者：

Poe, Sarah L. ^{[1
]}

Kobaslija, Muris ^{[1
]}

McQuade, D. Tyler ^{[1
]}

机构：

[1] Cornell Univ, Baker Lab, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 49期

关键词：

ONE-POT; BETA-NITROSTYRENES; OPPOSING REAGENTS; ORGANIC-SYNTHESIS; LINEAR-POLYMERS; CATALYSTS; BENZYLAMINE; BASES;

D O I：

10.1021/ja066476l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present a new microencapsulated catalyst and report its use in a tandem multicatalyst reaction. Using an encapsulation technique, we developed an active, site-isolated amine catalyst that is capable of catalyzing the addition of nitromethane to an aldehyde. When a second Lewis acid catalyst is added, the nitroalkene intermediate is trapped and converted to the corresponding Michael adduct. We show that if the amine catalyst is not encapsulated, the two catalysts cannot function together. Moreover, if the two reactions are performed in sequence rather than in tandem, the first reaction results in an undesired dinitro product and the desired Michael adduct is not formed. Copyright © 2006 American Chemical Society.

引用

页码：15586 / 15587

页数：2

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