CD4/CD8-lineage differentiation in the thymus: From nuclear effectors to membrane signals

被引：89

作者：

Bosselut, R ^{[1
]}

机构：

[1] NCI, Lab Immune Cell Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 07期

关键词：

D O I：

10.1038/nri1392

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During thymocyte development, immature thymocytes that express both CD4 and CD8 genes must choose either a helper CD4(+) or cytotoxic CD8(+) T-cell fate. Over the past two years, there have been some important advances regarding T-cell lineage choice, including the identification of transcription factors required for CD4 gene silencing by CD8-lineage cells (RUNX3) or for CD4(+) T-cell differentiation (GATA3), and a better understanding of how T-cell receptor (TCR) signalling correlates CD4/CD8-lineage differentiation to MHC specificity. This review summarizes these recent advances and highlights potential links between TCR signals and nuclear effectors of lineage differentiation.

引用

页码：529 / 540

页数：12

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