Effect of glucose tolerance status on PAI-1 plasma levels in overweight and obese subjects

被引:38
作者
Pannacciulli, N
De Mitrio, V
Marino, R
Giorgino, R
De Pergola, G
机构
[1] Univ Bari, Dept Emergency & Transplant, I-70121 Bari, Italy
[2] Univ Bari, Haemostasis & Thrombosis Ctr, Dept Internal Med Immunol & Infect Dis, I-70121 Bari, Italy
来源
OBESITY RESEARCH | 2002年 / 10卷 / 08期
关键词
plasminogen activator inhibitor-1; glucose tolerance; insulin resistance; central fat accumulation;
D O I
10.1038/oby.2002.98
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: The aim of our study was to examine whether plasminogen activator inhibitor-1 (PAI-1) plasma levels varied as a function of differences in glucose tolerance status independently of body fatness, body-fat distribution, and insulin sensitivity. Research Methods and Procedures: Plasma PAI-1 antigen levels, along with insulin resistance [measured by homeostatic model assessment (HOMA(IR))], central fat accumulation, body composition, blood pressure, and fasting concentrations of glucose, insulin, and lipids, were measured in 229 overweight and obese [body mass index (BMI) greater than or equal to25 kg/m(2)) subjects with normal glucose tolerance (NGT) and in 44 age- and BMI-matched subjects with impaired glucose tolerance (IGT). Results: Plasma PAI-1 antigen levels were significantly higher in IGT than in NGT subjects. Log PAI-1 was positively correlated with BMI, HOMA(IR), and log insulin, and inversely associated with high-density lipoprotein-cholesterol both in IGT and in NGT individuals. On the other hand, log PAI-1 was positively correlated with waist circumference, fat mass (FM), fat-free mass, systolic and diastolic blood pressure, and log triglycerides only in the NGT group. After multivariate analyses, the strongest determinants of PAI-1 levels were BMI, FM, waist circumference, and high-density lipoprotein cholesterol in the NGT group and only HOMAIR in the IGT cohort. Discussion: This study demonstrates that PAI-1 concentrations are higher in IGT than in NGT subjects. Furthermore, we suggest that the influences of total adiposity, central fat, and insulin resistance, main determinants of PAI-1 concentrations, are different according to the degree of glucose tolerance.
引用
收藏
页码:717 / 725
页数:9
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