Ontology for immunogenetics: the IMGT-ONTOLOGY

被引：106

作者：

Giudicelli, V ^{[1
]}

Lefranc, MP ^{[1
]}

机构：

[1] LIGM, Lab Immunogenet Mol, Inst Genet Humaine, UPR CNRS 1142, F-34396 Montpellier 5, France

来源：

BIOINFORMATICS | 1999年 / 15卷 / 12期

关键词：

D O I：

10.1093/bioinformatics/15.12.1047

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr:8104), created by M.-P. Lefranc, is an integrated database specializing in antigen receptors (immunoglobulins and T-cell receptors) and major histocompatibility complex (MHC) of all vertebrate species. IMGT accurate immunogenetics data ave based on the standardization of the biological knowledge provided by the 'ImMunoGeneTics' IMGT-ONTOLOGY. The IMGT-ONTOLOGY describes the classification and specification of terms needed for immunogenetics and bioinformatics. IMGT-ONTOLOGY covers four main concepts: 'IDENTIFICATION', 'DESCRIPTION', 'CLASSIFICATION' and 'OBTENTION'. These concepts allow an extensive and standardized description and characterization of immunoglobulin and T-cell receptor data. The controlled vocabulary and the annotation rules ave indispensable to ensure accuracy, consistency and coherence in IMGT. IMGT-ONTOLOGY allows scientists and clinicians to use, for the first time, identical terms with the same meaning in immunogenetics. It provides a semantic repository that will improve interoperability between specialist and generalist databases.

引用

页码：1047 / 1054

页数：8

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