A concise, asymmetric synthesis of tetramic acid derivatives

被引：23

作者：

Fustero, S ^{[1
]}

de la Torre, MG ^{[1
]}

Sanz-Cervera, JF ^{[1
]}

de Arellano, CR ^{[1
]}

Piera, J ^{[1
]}

Simón, A ^{[1
]}

机构：

[1] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Spain

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 21期

关键词：

D O I：

10.1021/ol026599k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A simple, asymmetric synthesis of tetramic acid derivatives is described in this paper. The key step is a carbonyl transfer from carbonyldiimidazole (CDI) to alpha-diimines (I) to form N-alkyl-4-alkylamino-5-methylenepyrrol-2-ones (II). In turn, these compounds can be easily transformed into tetramic acid derivatives (III) in two additional steps.

引用

页码：3651 / 3654

页数：4

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