Synthesis, Biological Evaluation, and Mode of Action of Pulsatilla Saponin D Derivatives as Promising Anticancer Agents

被引：10

作者：

Fang, Yuanying ^{[1
]}

Hu, Daoyong ^{[2
]}

Li, Huilan ^{[1
,3
]}

Hu, Jianguo ^{[4
]}

Liu, Yanhua ^{[4
]}

Li, Zhifeng ^{[1
]}

Xu, Guoliang ^{[3
]}

Chen, Lanying ^{[1
]}

Jin, Yi ^{[1
]}

Yang, Shilin ^{[1
]}

Yang, Zunhua ^{[4
]}

机构：

[1] Jiangxi Univ Tradit Chinese Med, Natl Engn Res Ctr Mfg Technol TCM Solid Preparat, Nanchang, Jiangxi, Peoples R China

[2] Nanchang Univ, Key Lab Oral Biomed, Affiliated Stomatol Hosp, Nanchang, Jiangxi, Peoples R China

[3] Jiangxi Univ Tradit Chinese Med, Res Ctr Differentiat & Dev Basic Theory Tradit Ch, Nanchang, Jiangxi, Peoples R China

[4] Jiangxi Univ Tradit Chinese Med, Coll Pharm, Nanchang, Jiangxi, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷

关键词：

Pulsatilla saponin D; synthesis; antiproliferative activity; acute toxicity; CHINENSIS BUNGE REGEL; HEDERACOLCHISIDE A(1); TRITERPENOID SAPONINS; ANTITUMOR-ACTIVITY; IN-VITRO; CYTOTOXICITY; TUMOR;

D O I：

10.3389/fphar.2019.01208

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

A series of ester and amide derivatives of triterpenoid saponin Pulsatilla saponin D (PSD) were designed, synthesized, and evaluated for their antiproliferative activity. Compounds 1 and 6 displayed 1.7-8.3 times more potent cytotoxicity (IC50 = 1.2-4.7 and 1.7-4.5 mu M, respectively) against five human tumor cell lines (SMMC-7721, MCF-7, NCI-H460, A549, and HCT-116) in vitro and lower acute toxicity to mice in vivo than did PSD. Furthermore, compound 6 was observed to show potent tumor growth inhibition against mice H22 hepatocellular cells (49.8% at 20 mg/kg) and induce cell cycle at G(1) phase and apoptosis in HCT-116 cells.

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页数：9

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