Cytomegalovirus Reinfections in Healthy Seroimmune Women

被引：147

作者：

Ross, Shannon A. ^{[1
]}

Arora, Nitin ^{[1
,3
]}

Novak, Zdenek ^{[1
]}

Fowler, Karen B. ^{[1
,2
,3
]}

Britt, William J. ^{[1
,4
]}

Boppana, Suresh B. ^{[1
,4
]}

机构：

[1] Univ Alabama, Dept Pediat, Birmingham, AL 35233 USA

[2] Univ Alabama, Dept Epidemiol, Birmingham, AL 35233 USA

[3] Univ Alabama, Dept Maternal & Child Hlth, Birmingham, AL 35233 USA

[4] Univ Alabama, Dept Microbiol, Birmingham, AL 35233 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 201卷 / 03期

关键词：

INFECTION; POPULATION; STRAIN; ANTIBODIES; IMMUNITY; EPITOPES; CHILDREN;

D O I：

10.1086/649903

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytomegalovirus (CMV) reinfections have been associated with damaging congenital infection and adverse outcomes in transplant recipients. To determine the frequency of and risk factors for CMV reinfections, 205 seropositive women were followed up prospectively. The appearance of new antibody specificity against 1 of 4 polymorphic epitopes was considered as evidence of CMV reinfection. Approximately one-third of the study participants (59 [29%] of 205) were noted to have CMV reinfection during follow-up. None of the exposure factors were associated with CMV reinfection. Women with antibodies against at least 1 of the 4 antigens at baseline had a 63% decreased risk of reinfection, suggesting a protective role for strain-specific immunity.

引用

页码：386 / 389

页数：4

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