Acquired cystic disease-associated renal tumors:: an immunohistochemical and fluorescence in situ hybridization study

被引:64
作者
Cossu-Rocca, Paolo
Eble, John N.
Zhang, Shaobo
Martignoni, Guido
Brunelli, Matteo
Cheng, Liang
机构
[1] Indiana Univ, Med Ctr, Dept Pathol, Indianapolis, IN 46202 USA
[2] Indiana Univ, Dept Lab Med, Indianapolis, IN 46204 USA
[3] Univ Sassari, Dipartimento Patol, I-07100 Sassari, Italy
[4] Univ Verona, Dipartimento Patol, I-37100 Verona, Italy
关键词
kidney tumors; end-stage renal disease; acquired cystic disease of kidney; calcium oxalate; cytogenetics; fluorescence in situ hybridization (FISH);
D O I
10.1038/modpathol.3800604
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
End-stage renal disease is associated with an increased incidence of renal cell neoplasms. Among these, recent studies have identified tumors with unusual histological patterns that do not fit into the categories recognized in the current classification system. These tumors often occur in kidneys with acquired cystic disease and are composed mainly of large eosinophilic cells arranged in solid, cribriform, acinar, or papillary patterns. They also contain deposits of calcium oxalate crystals. We investigated three eosinophilic epithelial tumors arising in kidneys with acquired cystic disease from three patients. Each of the tumors was composed of large eosinophilic cells arranged in solid, acinar, or tubulocystic architecture. Deposits of calcium oxalate crystals were present in each tumor. Hale's colloidal stain showed a positive cytoplasmic reaction in one of the neoplasms. Immunohistochemistry displayed positive results for CD10 (3/3), AE1/AE3 (3/3), alpha-methylacyl-CoA racemase (2/3), CAM5.2 (2/3), and vimentin (1/3). Reactions for epithelial membrane antigen, cytokeratin 7, and high molecular weight cytokeratin (34bE12) were negative. Fluorescence in situ hybridization analysis showed no losses or gains of chromosomes 1, 2, 6, 10, or 17 in one tumor. There were gains of chromosomes 1, 2, and 6 in two tumors. One of these tumors also showed gains of chromosome 10. Eosinophilic renal cell tumors associated with acquired cystic disease have immunophenotypes and genetic profiles distinct from the renal cell neoplasms recognized in the current classification of renal cell neoplasia, and should be considered as a distinct clinicopathologic entity in the spectrum of renal cell neoplasia.
引用
收藏
页码:780 / 787
页数:8
相关论文
共 33 条
[1]   Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma [J].
Brunelli, M ;
Eble, JN ;
Zhang, SB ;
Martignoni, G ;
Delahunt, B ;
Cheng, L .
MODERN PATHOLOGY, 2005, 18 (02) :161-169
[2]   Metanephric adenoma lacks the gains of chromosomes 7 and 17 and loss of Y that are typical of papillary renal cell carcinoma and papillary adenoma [J].
Brunelli, M ;
Eble, JN ;
Zhang, SB ;
Martignoni, G ;
Cheng, L .
MODERN PATHOLOGY, 2003, 16 (10) :1060-1063
[3]   Gains of chromosomes 7, 17, 12, 16, and 20 and loss of Y occur early in the evolution of papillary renal cell neoplasia:: A fluorescent in situ hybridization study [J].
Brunelli, M ;
Eble, JN ;
Zhang, SB ;
Martignoni, G ;
Cheng, L .
MODERN PATHOLOGY, 2003, 16 (10) :1053-1059
[4]   Atypical epithelial proliferations in acquired renal cystic disease harbor cytogenetic aberrations [J].
Cheuk, W ;
Lo, ESF ;
Chan, AKC ;
Chan, JKC .
HUMAN PATHOLOGY, 2002, 33 (07) :761-765
[5]   Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis [J].
Cossu-Rocca, P ;
Zhang, SB ;
Roth, LM ;
Eble, JN ;
Zheng, WX ;
Karim, FWA ;
Michael, H ;
Emerson, RE ;
Jones, TD ;
Hattab, EM ;
Cheng, L .
MODERN PATHOLOGY, 2006, 19 (04) :611-615
[6]   Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma [J].
Cossu-Rocca, P ;
Eble, JN ;
Delahunt, B ;
Zhang, SB ;
Martignoni, G ;
Brunelli, M ;
Cheng, L .
MODERN PATHOLOGY, 2006, 19 (04) :488-493
[7]   Prevalence of renal cell carcinoma in patients with ESRD pre-transplantation: A pathologic analysis [J].
Denton, MD ;
Magee, CC ;
Ovuworie, C ;
Mauiyyedi, S ;
Pascual, M ;
Colvin, RB ;
Cosimi, AB ;
Tolkoff-Rubin, N .
KIDNEY INTERNATIONAL, 2002, 61 (06) :2201-2209
[8]  
Dry SM, 1998, ARCH PATHOL LAB MED, V122, P260
[9]  
EBLE JN, 2004, TUMOURS KIDNEY HLTH
[10]   Losses of 1p and chromosome 14 in renal oncocytomas [J].
Füzesi, L ;
Frank, D ;
Nguyen, C ;
Ringert, RH ;
Bartels, H ;
Gunawan, B .
CANCER GENETICS AND CYTOGENETICS, 2005, 160 (02) :120-125