Losses of 1p and chromosome 14 in renal oncocytomas

被引：19

作者：

Füzesi, L

Frank, D

Nguyen, C

Ringert, RH

Bartels, H

Gunawan, B

机构：

[1] Univ Gottingen, Dept Pathol, D-37075 Gottingen, Germany

[2] Univ Heidelberg, Dept Internal Med 3, Heidelberg, Germany

[3] Univ Gottingen, Dept Urol, D-37075 Gottingen, Germany

[4] Evangel Krankenhaus Weende, Dept Urol, Gottingen, Germany

来源：

CANCER GENETICS AND CYTOGENETICS | 2005年 / 160卷 / 02期

关键词：

D O I：

10.1016/j.cancergencyto.2004.12.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We performed cytogenetic analyses of 8 renal oncocytomas to identify chromosomal regions involved in the tumorigenesis of oncocytomas. All cases showed chromosomal findings corresponding to established cytogenetic subsets of renal oncocytomas: 3 cases with normal karyotypes, 1 case with rearrangement of 11q, and 4 cases with losses of chromosome 14. In the latter cytogenetic subgroup, monosomy 14 was additionally accompanied by either monosomy I in 2 cases or loss of 1p in a third case, providing insights in the cytogenetic evolution of this subgroup. (c) 2005 Elsevier Inc. All rights reserved.

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页码：120 / 125

页数：6

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