Genetics of human obesity

被引：24

作者：

Clement, Karine ^{[1
]}

机构：

[1] Univ Paris 06, INSERM U755, Paris 75004, France

[2] Univ Paris 06, IFR58, Paris 75004, France

[3] CHRU Pitie Salpetriere, Serv Nutr, Hotel Dieu, F-75004 Paris, France

来源：

COMPTES RENDUS BIOLOGIES | 2006年 / 329卷 / 08期

关键词：

obesity; genetic; association study; linkage study; complexity;

D O I：

10.1016/j.crvi.2005.10.009

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We present the knowledge acquired in the field of the genetics of human obesity. The molecular approach proved to be powerful to define new syndromes associated to obesity. The pivotal role of leptin and melanocortin pathways were recognized but in rare obesity cases. In the commoner form of obesities, a multitude of polymorphisms located in genes and candidate regions participate in an individual susceptibility to weight gain in a permissive environment. The effects are often uncertain and the results not always confirmed. It is now necessary to integrate data of various origins (environment, genotype, expression) to clarify the domain.

引用

页码：608 / 622

页数：15

共 68 条

[1] ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes [J].

Abate, N ;

Chandalia, M ;

Satija, P ;

Adams-Huet, B ;

Grundy, SM ;

Sandeep, S ;

Radha, V ;

Deepa, R ;

Mohan, V .

DIABETES, 2005, 54 (04) :1207-1213

[2] Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution - A family study [J].

Baker, M ;

Gaukrodger, N ;

Mayosi, BM ;

Imrie, H ;

Farrall, M ;

Watkins, H ;

Connell, JMC ;

Avery, PJ ;

Keavney, B .

DIABETES, 2005, 54 (08) :2492-2496

[3] The common variants/multiple disease hypothesis of common complex genetic disorders [J].

Becker, KG .

MEDICAL HYPOTHESES, 2004, 62 (02) :309-317

[4] A role for β-melanocyte-stimulating hormone in human body-weight regulation [J].

Biebermann, H ;

Castañeda, TR ;

van Landeghem, F ;

von Deimling, A ;

Escher, F ;

Brabant, G ;

Hebebrand, J ;

Hinney, A ;

Tschöp, MH ;

Grüters, A ;

Krude, H .

CELL METABOLISM, 2006, 3 (02) :141-146

[5] GAD2 on chromosome 10p12 is a candidate gene for human obesity [J].

Boutin, P ;

Dina, C ;

Vasseur, F ;

Dubois, S ;

Corset, L ;

Séron, K ;

Bekris, L ;

Cabellon, J ;

Neve, B ;

Vasseur-Delannoy, V ;

Chikri, M ;

Charles, MA ;

Clement, K ;

Lernmark, A ;

Froguel, P .

PLOS BIOLOGY, 2003, 1 (03) :361-371

[6] Binge eating as a major phenotype of melanocortin 4 receptor gene mutations [J].

Branson, R ;

Potoczna, N ;

Kral, JG ;

Lentes, K ;

Hoehe, MR ;

Horber, FF .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (12) :1096-1103

[7]

CARROLL L, 2005, PEPTIDES

[8] A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism [J].

Challis, BG ;

Pritchard, LE ;

Creemers, JWM ;

Delplanque, J ;

Keogh, JM ;

Luan, J ;

Wareham, NJ ;

Yeo, GSH ;

Bhattacharyya, S ;

Froguel, P ;

White, A ;

Farooqi, IS ;

O'Rahilly, S .

HUMAN MOLECULAR GENETICS, 2002, 11 (17) :1997-2004

[9] Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass [J].

Chen, AS ;

Marsh, DJ ;

Trumbauer, ME ;

Frazier, EG ;

Guan, XM ;

Yu, H ;

Rosenblum, CI ;

Vongs, A ;

Feng, Y ;

Cao, LH ;

Metzger, JM ;

Strack, AM ;

Camacho, RE ;

Mellin, TN ;

Nunes, CN ;

Min, W ;

Fisher, J ;

Gopal-Truter, S ;

MacIntyre, DE ;

Chen, HY ;

Van der Ploeg, LHT .

NATURE GENETICS, 2000, 26 (01) :97-102

[10] Molecular physiology of syndromic obesities in humans [J].

Chung, WK ;

Leibel, RL .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2005, 16 (06) :267-272

← 1 2 3 4 5 6 7 →