Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography

被引：20

作者：

Hansen, A

Kumar, A

Wolf, D

Frankenbergerova, K

Filusch, A

Gross, ML

Mueller, S

Katus, H

Kuecherer, H

机构：

[1] Univ Heidelberg, Dept Cardiol, D-69115 Heidelberg, Germany

[2] Univ Heidelberg, Dept Pathol, D-69115 Heidelberg, Germany

[3] Wyeth Res, Cambridge, MA USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2004年 / 44卷 / 04期

关键词：

D O I：

10.1016/j.jacc.2004.05.052

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES The purpose was to examine the cardioprotective effects of recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig) in ischemia-reperfusion injury by real-time myocardial contrast echocardiography (MCE). BACKGROUND P-selectin mediates leukocyte recruitment into areas of inflammation. METHODS Sixteen pigs underwent 45 min of left anterior descending coronary artery occlusion followed by reperfusion and received rPSGL-Ig or vehicle. To assess changes in myocardial perfusion (A x beta), MCE was performed. RESULTS After 120 min of reperfusion, A x beta in the risk area was higher (0.84 +/- 0.15 dB/s vs. 0.28 +/- 0.1 dB/s, p < 0.0001), and the infarct size was lower (30.3 +/- 12% vs. 57 +/- 14%, p = 0.002) in the rPSGL-Ig group compared with the vehicle group. CONCLUSIONS Recombinant PSGL-Ig improved postischemic reflow accurately detected by real-time MCE. (C) 2004 by the American College of Cardiology Foundation.

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页码：887 / 891

页数：5

相关论文

共 16 条

[1] PROGRESSIVE IMPAIRMENT OF REGIONAL MYOCARDIAL PERFUSION AFTER INITIAL RESTORATION OF POSTISCHEMIC BLOOD-FLOW [J].

AMBROSIO, G ;

WEISMAN, HF ;

MANNISI, JA ;

BECKER, LC .

CIRCULATION, 1989, 80 (06) :1846-1861

[2] THE BINDING-AFFINITY OF HUMAN-IGG FOR ITS HIGH-AFFINITY FC RECEPTOR IS DETERMINED BY MULTIPLE AMINO-ACIDS IN THE CH2 DOMAIN AND IS MODULATED BY THE HINGE REGION [J].

CANFIELD, SM ;

MORRISON, SL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (06) :1483-1491

[3]

DAGALIUTO L, 2000, CIRCULATION, V102, P3111

[4] Clinical implications of the 'no reflow' phenomenon - A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction [J].

Ito, H ;

Maruyama, A ;

Iwakura, K ;

Takiuchi, S ;

Masuyama, T ;

Hori, M ;

Higashino, Y ;

Fujii, K ;

Minamino, T .

CIRCULATION, 1996, 93 (02) :223-228

[5] Adhesion molecules in different treatments of acute myocardial infarction [J].

Kerner, T ;

Ahlers, O ;

Reschreiter, H ;

Bührer, C ;

Möckel, M ;

Gerlach, H .

CRITICAL CARE, 2001, 5 (03) :145-150

[6] The use of cylexin (CY-1503) in prevention of reperfusion lung injury in patients undergoing pulmonary thromboendarterectomy [J].

Kerr, KM ;

Auger, WR ;

Marsh, JJ ;

Comito, RM ;

Fedullo, RL ;

Smits, GJ ;

Kapelanski, DP ;

Fedullo, PF ;

Channick, RN ;

Jamieson, SW ;

Moser, KM .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (01) :14-20

[7] Recombinant soluble form of PSGL-1 accelerates thrombolysis and prevents reocclusion in a porcine model [J].

Kumar, A ;

Villani, MP ;

Patel, UK ;

Keith, JC ;

Schaub, RG .

CIRCULATION, 1999, 99 (10) :1363-1369

[8] Effects of glycoprotein IIb/IIIa inhibition on microvascular flow after coronary reperfusion - A quantitative myocardial contrast echocardiography study [J].

Kunichika, H ;

Ben-Yehuda, O ;

Lafitte, S ;

Kunichika, N ;

Peters, B ;

DeMaria, AN .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 43 (02) :276-283

[9] Selectin blockade reduces neutrophil interaction with platelets at the site of deep arterial injury by angioplasty in pigs [J].

Merhi, Y ;

Provost, P ;

Chauvet, P ;

Théorêt, JF ;

Phillips, ML ;

Latour, JG .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (02) :372-377

[10] A SULFATED PEPTIDE SEGMENT AT THE AMINO-TERMINUS OF PSGL-1 IS CRITICAL FOR P-SELECTIN BINDING [J].

SAKO, D ;

COMESS, KM ;

BARONE, KM ;

CAMPHAUSEN, RT ;

CUMMING, DA ;

SHAW, GD .

CELL, 1995, 83 (02) :323-331