Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography

被引：20

作者：

Hansen, A

Kumar, A

Wolf, D

Frankenbergerova, K

Filusch, A

Gross, ML

Mueller, S

Katus, H

Kuecherer, H

机构：

[1] Univ Heidelberg, Dept Cardiol, D-69115 Heidelberg, Germany

[2] Univ Heidelberg, Dept Pathol, D-69115 Heidelberg, Germany

[3] Wyeth Res, Cambridge, MA USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2004年 / 44卷 / 04期

关键词：

D O I：

10.1016/j.jacc.2004.05.052

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES The purpose was to examine the cardioprotective effects of recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig) in ischemia-reperfusion injury by real-time myocardial contrast echocardiography (MCE). BACKGROUND P-selectin mediates leukocyte recruitment into areas of inflammation. METHODS Sixteen pigs underwent 45 min of left anterior descending coronary artery occlusion followed by reperfusion and received rPSGL-Ig or vehicle. To assess changes in myocardial perfusion (A x beta), MCE was performed. RESULTS After 120 min of reperfusion, A x beta in the risk area was higher (0.84 +/- 0.15 dB/s vs. 0.28 +/- 0.1 dB/s, p < 0.0001), and the infarct size was lower (30.3 +/- 12% vs. 57 +/- 14%, p = 0.002) in the rPSGL-Ig group compared with the vehicle group. CONCLUSIONS Recombinant PSGL-Ig improved postischemic reflow accurately detected by real-time MCE. (C) 2004 by the American College of Cardiology Foundation.

引用

页码：887 / 891

页数：5