Chemotherapeutic targeting of myeloid-derived suppressor cells

被引：14

作者：

Alizadeh, Darya ^{[1
,2
]}

Katsanis, Emmanuel ^{[1
,2
,3
,4
]}

Larmonier, Nicolas ^{[1
,2
,3
,4
]}

机构：

[1] Univ Arizona, Dept Pediat, Ctr Canc, Steele Childrens Res Ctr, Tucson, AZ 85721 USA

[2] Univ Arizona, Canc Biol Grad Program, Tucson, AZ USA

[3] Univ Arizona, Dept Immunobiol, Tucson, AZ USA

[4] Univ Arizona, BIO5, Tucson, AZ USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期

关键词：

cancer; chemoimmunomodulation; doxorubicin; helper T lymphocytes; myeloid-derived suppressor cells; ROS;

D O I：

10.4161/onci.27359

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Myeloid-derived suppressor cells (MDSCs), which expand in cancer-bearing hosts, contribute to the escape of malignant cells from immune destruction and impair the efficacy of immunotherapeutic interventions. We have recently demonstrated that the conventional chemotherapeutic agent doxorubicin selectively eliminates MDSCs, hence promoting the activity of immune effector cells and improving the therapeutic profile of adoptively transferred helper T lymphocytes.

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页数：3

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