Pathogenesis and management of bone lesions in multiple myeloma

被引：51

作者：

Bataille, R

Manolagas, SC

Berenson, JR

机构：

[1] UNIV ARKANSAS MED SCI HOSP, CTR OSTEOPOROSIS & METAB BONE DIS, LITTLE ROCK, AR 72205 USA

[2] W LOS ANGELES VET AFFAIRS MED CTR, LOS ANGELES, CA 90073 USA

[3] UNIV CALIF LOS ANGELES, SCH MED, LOS ANGELES, CA 90024 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1997年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0889-8588(05)70435-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Osteolytic lesions are among the hallmarks of multiple myeloma (MM). On the other hand, they are rare in B cell malignancies other than MM. Data have shown a close relationship between myeloma cell. growth factors and factors involved in the occurrence of bone lesions in MM. Biophosphonates, which are potent inhibitors of bone resorption to control MM-induced hypercalcemia, are of interest due to their ability to slow the progression of MM bone disease.

引用

页码：349 / +

页数：1

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[41] ESSENTIAL ROLE OF MACROPHAGE COLONY-STIMULATING FACTOR IN THE OSTEOCLAST DIFFERENTIATION SUPPORTED BY STROMAL CELLS [J].