Nanodiamonds with silicon vacancy defects for nontoxic photostable fluorescent labeling of neural precursor cells

被引：69

作者：

Merson, Tobias D. ^{[1
,2
,3
,4
,5
]}

Castelletto, Stefania ^{[5
]}

Aharonovich, Igor ^{[6
]}

Turbic, Alisa ^{[3
,4
]}

Kilpatrick, Trevor J. ^{[1
,2
,3
,4
]}

Turnley, Ann M. ^{[3
,4
]}

机构：

[1] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3010, Australia

[2] Univ Melbourne, Florey Dept Neurosci & Mental Hlth, Parkville, Vic 3010, Australia

[3] Univ Melbourne, Melbourne Neurosci Inst, Parkville, Vic 3010, Australia

[4] Univ Melbourne, Dept Anat & Neurosci, Ctr Neurosci Res, Parkville, Vic 3010, Australia

[5] RMIT Univ, Sch Aerosp Mech & Mfg Engn, Melbourne, Vic 3000, Australia

[6] Univ Technol Sydney, Sch Phys & Adv Mat, Ultimo, NSW 2007, Australia

来源：

OPTICS LETTERS | 2013年 / 38卷 / 20期

基金：

澳大利亚研究理事会;

关键词：

NITROGEN; DIAMOND;

D O I：

10.1364/OL.38.004170

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Nanodiamonds (NDs) containing silicon vacancy (SiV) defects were evaluated as a potential biomarker for the labeling and fluorescent imaging of neural precursor cells (NPCs). SiV-containing NDs were synthesized using chemical vapor deposition and silicon ion implantation. Spectrally, SiV-containing NDs exhibited extremely stable fluorescence and narrow bandwidth emission with an excellent signal to noise ratio exceeding that of NDs containing nitrogen-vacancy centers. NPCs labeled with NDs exhibited normal cell viability and proliferative properties consistent with biocompatibility. We conclude that SiV-containing NDs are a promising biomedical research tool for cellular labeling and optical imaging in stem cell research. (C) 2013 Optical Society of America

引用

页码：4170 / 4173

页数：4

共 18 条

[1] Engineering chromium-related single photon emitters in single crystal diamonds [J].

Aharonovich, I. ;

Castelletto, S. ;

Johnson, B. C. ;

McCallum, J. C. ;

Prawer, S. .

NEW JOURNAL OF PHYSICS, 2011, 13

[2] Radiative and nonradiative decay rates in chromium-related centers in nanodiamonds [J].

Castelletto, S. ;

Boretti, A. .

OPTICS LETTERS, 2011, 36 (21) :4224-4226

[3] Imaging and Quantum-Efficiency Measurement of Chromium Emitters in Diamond [J].

Castelletto, S. ;

Aharonovich, I. ;

Gibson, B. C. ;

Johnson, B. C. ;

Prawer, S. .

PHYSICAL REVIEW LETTERS, 2010, 105 (21)

[4] OPTICAL STUDIES OF 1.945 EV VIBRONIC BAND IN DIAMOND [J].

DAVIES, G ;

HAMER, MF .

PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL AND PHYSICAL SCIENCES, 1976, 348 (1653) :285-298

[5] The twelve-line 1.682eV luminescence center in diamond and the vacancy-silicon complex [J].

Goss, JP ;

Jones, R ;

Breuer, SJ ;

Briddon, PR ;

Oberg, S .

PHYSICAL REVIEW LETTERS, 1996, 77 (14) :3041-3044

[6] Molecular Imaging of Stem Cells: Tracking Survival, Biodistribution, Tumorigenicity, and Immunogenicity [J].

Gu, Eugene ;

Chen, Wen-Yi ;

Gu, Jay ;

Burridge, Paul ;

Wu, Joseph C. .

THERANOSTICS, 2012, 2 (04) :335-345

[7] Functionality is Key: Recent Progress in the Surface Modification of Nanodiamond [J].

Krueger, Anke ;

Lang, Daniel .

ADVANCED FUNCTIONAL MATERIALS, 2012, 22 (05) :890-906

[8] Nanoscale Nuclear Magnetic Resonance with a Nitrogen-Vacancy Spin Sensor [J].

Mamin, H. J. ;

Kim, M. ;

Sherwood, M. H. ;

Rettner, C. T. ;

Ohno, K. ;

Awschalom, D. D. ;

Rugar, D. .

SCIENCE, 2013, 339 (6119) :557-560

[9] The transcriptional coactivator Querkopf controls adult neurogenesis [J].

Merson, Tobias D. ;

Dixon, Mathew P. ;

Collin, Caitlin ;

Rietze, Rodney L. ;

Bartlett, Perry F. ;

Thomas, Tim ;

Voss, Anne K. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (44) :11359-11370

[10]

Mochalin VN, 2012, NAT NANOTECHNOL, V7, P11, DOI [10.1038/nnano.2011.209, 10.1038/NNANO.2011.209]

← 1 2 →