Phospholipid signalling through phospholipase D and phosphatidic acid

被引：84

作者：

Cazzolli, Rosanna

Shemon, Anne N.

Fang, Michelle Q.

Hughes, William E.

机构：

[1] Garvan Inst Med Res, Phospholipid Biol Grp, Sydney, NSW 2010, Australia

[2] Garvan Inst Med Res, Mol Imaging Facil, Sydney, NSW 2010, Australia

[3] Univ Sydney, Nepean Hosp, Dept Med, Sydney, NSW 2006, Australia

[4] Univ New S Wales, St Vincents Hosp, Dept Med, Kensington, NSW 2033, Australia

来源：

IUBMB LIFE | 2006年 / 58卷 / 08期

关键词：

phospholipase D; phosphatidic acid; protein kinase C; ARF; Rho; membrane curvature; vesicle trafficking;

D O I：

10.1080/15216540600871142

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the predominant membrane phospholipid, phosphatidylcholine producing phosphatidic acid and free choline. This activity can participate in signal transduction pathways and impact on vesicle trafficking for secretion and endocytosis, as well as receptor signalling. Phospholipids can regulate PLD activity directly, through specific intermolecular interactions, or indirectly, through their effect on the localization or activity of PLD's protein effectors. This short review highlights these various phospholipid inputs into the regulation of PLD activity and also reviews potential roles for PLD-generated phosphatidic acid, particularly a mechanism by which the phospholipid may participate in the process of vesicular trafficking.

引用

页码：457 / 461

页数：5

共 30 条

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