Design of chelate ring-opening platinum anticancer complexes: Reversible binding to guanine

被引：43

作者：

Habtemariam, A ^{[1
]}

Sadler, PJ ^{[1
]}

机构：

[1] UNIV LONDON, BIRKBECK COLL, DEPT CHEM, LONDON WC1H 0PP, ENGLAND

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 15期

关键词：

D O I：

10.1039/cc9960001785

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chelate ring-opening in bis(aminophosphine) complexes of platinum(II) can be controlled by the substituents on N and P under biologically relevant conditions of pH and Cl- concentration; selective and reversible binding to the DNA base guanine can be achieved as well as cytotoxicity towards cancer cell lines.

引用

页码：1785 / 1786

页数：2

共 11 条

[1] PLATINUM(II) COMPLEXES OF UNSYMMETRICAL, POTENTIALLY BIDENTATE LIGANDS [J].

ANDERSON, GK ;

KUMAR, R .

INORGANIC CHEMISTRY, 1984, 23 (24) :4064-4068

[2] METAL-COMPLEXES OF FUNCTIONALIZED PHOSPHINES .1. SYNTHESIS AND CHARACTERIZATION OF 2-DIPHENYLPHOSPHINOETHYLAMINES AND SOME OF THEIR COMPLEXES WITH PLATINUM - X-RAY STRUCTURE OF [PT(PH2PCH2CH2NHBU(TERT))(PH2PCH2CH2NHBU(TERT).HCL)CL]CL.H2O [J].

BASSETT, M ;

DAVIES, DL ;

NEILD, J ;

PROUSE, LJS ;

RUSSELL, DR .

POLYHEDRON, 1991, 10 (4-5) :501-507

[3]

Berners-Price S.J., 1988, Struct. Bonding, V70, P27

[4] STEREOSPECIFIC HYDROGEN-BONDING IN MONONUCLEOTIDE ADDUCTS OF PLATINUM ANTICANCER COMPLEXES IN AQUEOUS-SOLUTION [J].

BERNERSPRICE, SJ ;

FREY, U ;

RANFORD, JD ;

SADLER, PJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (19) :8649-8659

[5] DELTA-R RING CONTRIBUTIONS TO P-31 NMR PARAMETERS OF TRANSITION-METAL-PHOSPHORUS CHELATE COMPLEXES [J].

GARROU, PE .

CHEMICAL REVIEWS, 1981, 81 (03) :229-266

[6]

HABTEMARIAM A., UNPUB

[7] ON THE COORDINATION CHEMISTRY OF PHOSPHINES AND PHOSPHINE OXIDES .28. TRANSITION-METAL AMINOALKYLPHOSPHINE COMPLEXES .2. PALLADIUM AND PLATINUM COMPLEXES [J].

ISSLEIB, K ;

KIPKE, A .

ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE, 1980, 464 (05) :176-186

[8]

PREGOSIN PS, 1987, PHOSPHORUS 31 NMR SP, V8, P465

[9] Improved understanding in platinum antitumour chemistry [J].

Reedijk, J .

CHEMICAL COMMUNICATIONS, 1996, (07) :801-806

[10]

TOBE ML, 1972, INORGANIC REACTION M

← 1 2 →