Asymmetric catalysis with "planar-chiral" derivatives of 4-(dimethylamino)pyridine

被引：415

作者：

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2004年 / 37卷 / 08期

关键词：

D O I：

10.1021/ar030051b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Whereas chiral Lewis acid catalysis has been intensively investigated, chiral Lewis base (nucleophilic) catalysis has been comparatively neglected. We have developed "planar-chiral" derivatives of 4-(dimethylamino)pyridine (DMAP), a highly versatile nucleophilic catalyst, that are effective in a diverse array of processes, including the Staudinger synthesis of beta-lactams, the acylation of silyl ketene acetals, and the kinetic resolution of amines.

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页码：542 / 547

页数：6

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