A useful acylation method using trichloroacetonitrile and triphenylphosphine for solid phase organic synthesis

被引：16

作者：

Vágó, I ^{[1
]}

Greiner, I ^{[1
]}

机构：

[1] Gedeon Richter Chem Works Ltd, Chem Works, H-1103 Budapest, Hungary

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 34期

关键词：

solid phase synthesis; acylation; acyl chloride;

D O I：

10.1016/S0040-4039(02)01241-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel acylation procedure was developed for polymer supported synthesis, with in situ generated acyl chlorides using trichloroacetonitrile and triphenylphosphine. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：6039 / 6041

页数：3

共 5 条

[1]

Benz G, 1991, COMPREHENSIVE ORGANI, V6, P381

[2] Merrifield, alpha-methoxyphenyl (MAMP) resin; A new versatile solid support for the synthesis of secondary amides. [J].

Brown, DS ;

Revill, JM ;

Shute, RE .

TETRAHEDRON LETTERS, 1998, 39 (46) :8533-8536

[3] O-BENZOTRIAZOLYL-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE AS COUPLING REAGENT FOR THE SYNTHESIS OF PEPTIDES OF BIOLOGICAL INTEREST [J].

DOURTOGLOU, V ;

GROSS, B ;

LAMBROPOULOU, V ;

ZIOUDROU, C .

SYNTHESIS-STUTTGART, 1984, (07) :572-574

[4] A mild and efficient procedure for the preparation of acid chlorides from carboxylic acids [J].

Jang, DO ;

Park, DJ ;

Kim, J .

TETRAHEDRON LETTERS, 1999, 40 (29) :5323-5326

[5] SOLID PHASE PEPTIDE SYNTHESIS .1. SYNTHESIS OF A TETRAPEPTIDE [J].

MERRIFIELD, RB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (14) :2149-&

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