Methylation and deamination of CpGs generate p53-binding sites on a genomic scale

被引：48

作者：

Zemojtel, Tomasz ^{[1
]}

Kielbasa, Szymon M. ^{[1
]}

Arndt, Peter F. ^{[1
]}

Chung, Ho-Ryun ^{[1
]}

Vingron, Martin ^{[1
]}

机构：

[1] Max Planck Inst Mol Genet, Dept Computat Mol Biol, D-14195 Berlin, Germany

来源：

TRENDS IN GENETICS | 2009年 / 25卷 / 02期

关键词：

P53; TRANSCRIPTION-FACTOR; RESPONSE ELEMENTS; REPEATED SEQUENCES; BINDING-SITES; ALU FAMILY; EVOLUTION; EXPANSION; NETWORK;

D O I：

10.1016/j.tig.2008.11.005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The formation of transcription-factor-binding sites is an important evolutionary process. Here, we show that methylation and deamination of CpG dinucleotides generate in vivo p53-binding sites in numerous Alu elements and in non-repetitive DNA in a species-specific manner. In light of this, we propose that the deamination of methylated CpGs constitutes a universal mechanism for de novo generation of various transcription-factor-binding sites in Alus.

引用

页码：63 / 66

页数：4

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