Functions and pathologies of BiP and its interaction partners

被引：167

作者：

Dudek, J. ^{[1
]}

Benedix, J. ^{[1
]}

Cappel, S. ^{[1
]}

Greiner, M. ^{[1
]}

Jalal, C. ^{[1
]}

Mueller, L. ^{[1
]}

Zimmermann, R. ^{[1
]}

机构：

[1] Univ Saarland, D-66421 Homburg, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 09期

关键词：

BiP; ERj proteins; nucleotide exchange factors; unfolded protein response; haemolytic uraemic syndrome; Marinesco-Sjogren syndrome; polycystic liver disease; Wolcott-Rallison syndrome; MARINESCO-SJOGREN-SYNDROME; ENDOPLASMIC-RETICULUM STRESS; CHAIN BINDING-PROTEIN; ESCHERICHIA-COLI DNAJ; NUCLEOTIDE EXCHANGE FACTOR; WOLCOTT-RALLISON-SYNDROME; POLYCYSTIC LIVER-DISEASE; DOG PANCREAS MICROSOMES; MOLECULAR CHAPERONE; ER STRESS;

D O I：

10.1007/s00018-009-8745-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The endoplasmic reticulum (ER) is involved in a variety of essential and interconnected processes in human cells, including protein biogenesis, signal transduction, and calcium homeostasis. The central player in all these processes is the ER-lumenal polypeptide chain binding protein BiP that acts as a molecular chaperone. BiP belongs to the heat shock protein 70 (Hsp70) family and crucially depends on a number of interaction partners, including co-chaperones, nucleotide exchange factors, and signaling molecules. In the course of the last five years, several diseases have been linked to BiP and its interaction partners, such as a group of infectious diseases that are caused by Shigella toxin producing E. coli. Furthermore, the inherited diseases Marinesco-Sjogren syndrome, autosomal dominant polycystic liver disease, Wolcott-Rallison syndrome, and several cancer types can be considered BiP-related diseases. This review summarizes the physiological and pathophysiological characteristics of BiP and its interaction partners.

引用

页码：1556 / 1569

页数：14

共 147 条

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