ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane

被引：52

作者：

Blau, M

Mullapudi, S

Becker, T

Dudek, J

Zimmermann, R

Penczek, PA

Beckmann, R

机构：

[1] Univ Med Sch Berlin, Charite, Inst Biochem, D-10117 Berlin, Germany

[2] Univ Texas, Houston Med Sch, Houston, TX 77030 USA

[3] Univ Saarland, D-66421 Homburg, Germany

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2005年 / 12卷 / 11期

关键词：

D O I：

10.1038/nsmb998

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ribosomes translating secretory and membrane proteins are targeted to the endoplasmic reticulum membrane and attach to the protein-conducting channel and ribosome-associated membrane proteins (RAMPs). Recently, a new RAMP, ERj1p, has been identified that recruits BiP to ribosomes and regulates translational activity. Here we present the cryo-EM structure of a ribosome-ERj1p complex, revealing how ERj1p coordinates the ribosome at the membrane and how allosteric effects may mediate ERj1p's regulatory activity.

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页码：1015 / 1016

页数：2

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