Stealth star polymers: A new high-loading scaffold for liquid-phase organic synthesis

被引：38

作者：

Reed, NN

Janda, KD

机构：

[1] Scripps Res Inst, Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 09期

关键词：

D O I：

10.1021/ol005764y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyethylene glycol (PEG) has proven to be a versatile soluble-polymer support for organic synthesis, though the use of PEG has been limited by its relatively low loading (0.5 mmol/g or less). We have developed a new high-loading (1 mmol/g) soluble-star polymer based on a cyclotriphosphazene core with PEG arms that exhibit superior precipitation properties compared with those of linear PEG. Additionally, the heterocyclic core does not add interfering signals to the H-1 or C-13 NMR.

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页码：1311 / 1313

页数：3

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