The dengue virus non-structural 1 protein: Risks and benefits

被引：61

作者：

Amorim, Jaime Henrique ^{[1
]}

dos Santos Alves, Rubens Prince ^{[1
]}

Boscardin, Silvia Beatriz ^{[2
]}

de Souza Ferreira, Luis Carlos ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Microbiol, Vaccine Dev Lab, BR-05508000 Sao Paulo, Brazil

[2] Univ Sao Paulo, Dept Parasitol, Lab Antigen Targeting Dendrit Cells, BR-05508000 Sao Paulo, Brazil

来源：

VIRUS RESEARCH | 2014年 / 181卷

基金：

巴西圣保罗研究基金会;

关键词：

Dengue virus; NS1; protein; Pathogenesis; Antiviral; Vaccine; Diagnosis; CD8(-) DENDRITIC CELLS; NS1; PROTEIN; PROTECTIVE EFFICACY; ENDOTHELIAL-CELLS; GLYCOPROTEIN NS1; LETHAL CHALLENGE; DNA VACCINE; RAPID TEST; T-CELLS; ANTIGEN;

D O I：

10.1016/j.virusres.2014.01.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The dengue virus (DENV) non-structural 1 (NS1) protein plays a critical role in viral RNA replication and has a central position in DENV pathogenesis. DENV NS1 is a glycoprotein expressed in infected mammalian cells as soluble monomers that dimerize in the lumen of the endoplasmic reticulum; NS1 is subsequently transported to the cell surface, where it remains membrane associated or is secreted into the extracellular milieu as a hexameric complex. During the last three decades, the DENV NS1 protein has also been intensively investigated as a potential target for vaccines antiviral drugs. In addition, NS1 is the major diagnostic marker for dengue infection. This review highlights some important issues regarding the role of NS1 in DENV pathogenesis and its biotechnological applications, both as a target for the development of safe and effective vaccines and antiviral drugs and as a tool for the generation of accurate diagnostic methods. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：53 / 60

页数：8

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