Polycomb repression: from cellular memory to cellular proliferation and cancer

被引：188

作者：

Jacobs, JJL ^{[1
]}

van Lohuizen, M ^{[1
]}

机构：

[1] Netherlands Canc Inst, Dept Mol Genet, NL-1066 CX Amsterdam, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2002年 / 1602卷 / 02期

关键词：

polycomb; epigenetic transcriptional repression; chromatin; cancer; cell proliferation; oncogene;

D O I：

10.1016/S0304-419X(02)00052-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcriptional repressors of the Polycomb group (PcG), together with the counteracting Trithorax group (TrxG) proteins, establish a form of cellular memory by regulating gene expression in a heritable fashion at the level of chromatin. This cellular memory function is required for a correct cell fate/behavior, which is not only crucial during development for the generation of a correct body plan but also later in life to prevent cellular transformation. Here, we summarize the rapidly accumulating data that implicate several mammalian PcG members in the control of cellular proliferation and tumorigenesis. (C) 2002 Elsevier Science B.V All rights reserved.

引用

页码：151 / 161

页数：11

共 97 条

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