D-Cycloserine facilitates extinction of a cocaine-induced conditioned place preference

被引：134

作者：

Botreau, Fanny ^{[1
]}

Paolone, Giovanna ^{[1
]}

Stewart, Jane ^{[1
]}

机构：

[1] Concordia Univ, Ctr Studies Behav Neurobiol, Dept Psychol, Montreal, PQ H4B 1R6, Canada

来源：

BEHAVIOURAL BRAIN RESEARCH | 2006年 / 172卷 / 01期

基金：

加拿大健康研究院;

关键词：

D-Cycloserine; conditioned place preference; extinction; cocaine; consolidation;

D O I：

10.1016/j.bbr.2006.05.012

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];

摘要：

D-Cycloserine, a partial NMDA agonist, significantly accelerated extinction of a cocaine-induced conditioned place preference (CPP) when rats were given systemic injections immediately, but not 4 h, after each extinction trial. Infusions directly into the basolateral amygdala had a similar effect. The facilitative effect of D-cycloserine on the extinction of appetitive conditioning is consistent with the idea of the formation of new learned associations during extinction. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：173 / 178

页数：6

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