Structural energetics of protein folding and binding

被引：46

作者：

Edgcomb, SP ^{[1
]}

Murphy, KP ^{[1
]}

机构：

[1] Univ Iowa, Dept Biochem, Iowa City, IA 52246 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2000年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0958-1669(99)00055-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural energetics is a method for calculating the energetics of protein folding and binding reactions as a function of temperature. This approach allows measured energetics to be interpreted with regards to the protein structure and the prediction of energetics from known structures. Recent advances include improvements in the parameterization of enthalpy, entropy and heat capacity terms and new applications, especially with regards to understanding dynamic properties of proteins and how these are affected by ligand binding.

引用

页码：62 / 66

页数：5

共 48 条

[1]

Amzel LM, 1997, PROTEINS, V28, P144

[2] PROTEIN-FOLDING INTERMEDIATES - NATIVE-STATE HYDROGEN-EXCHANGE [J].