Screening for in vivo (anti)estrogenic and (anti)androgenic activities of technical and formulated deltamethrin

被引：23

作者：

Andrade, AJM ^{[1
]}

Araújo, S ^{[1
]}

Santana, GM ^{[1
]}

Ohi, M ^{[1
]}

Dalsenter, PR ^{[1
]}

机构：

[1] Univ Fed Parana, Setor Ciencias Biol, Dept Farmacol, Curitiba, Parana, Brazil

来源：

REGULATORY TOXICOLOGY AND PHARMACOLOGY | 2002年 / 35卷 / 03期

关键词：

endocrine disruptors; screening; Hershberger assay; uterotrophic assay; deltamethrin;

D O I：

10.1006/rtph.2002.1554

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Concern over the possibility of hormonal systems being disrupted by chemicals in the environment has led to the development of assays to detect such chemicals. Technical and formulated deltamethrin, a widely used synthetic pyrethroid pesticide, was screened for (anti)estrogenic and (anti) androgenic activities by means of two major in vivo short-term screening tests: the uterotrophic and Hershberger assays. The results reported here indicate the absence of in vivo (anti) estrogenic and (anti) androgenic activities for both technical and formulated deltamethrin at the dose levels tested (2.0 and 4.0 mg/kg/day). However, further tests, including in vitro screening assays, are required to characterize fully the lack of endocrine action of these chemicals. (C) 2002 Elsevier Science (USA).

引用

页码：379 / 382

页数：4

共 13 条

[1]

[Anonymous], 1997, EPA630R96012

[2] Failure to confirm estrogenic activity for benzoic acid and clofibrate: Implications for lists of endocrine-disrupting agents [J].

Ashby, J ;

Lefevre, PA ;

Odum, J ;

Tinwell, H ;

Kennedy, SJ ;

Beresford, N ;

Sumpter, JP .

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 1997, 26 (01) :96-101

[3] Preliminary evaluation of the major protocol variables for the Hershberger castrated male rat assay for the detection of androgens, antiandrogens, and metabolic modulators [J].

Ashby, J ;

Lefevre, PA .

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2000, 31 (01) :92-105

[4] Endocrine disrupters - testing strategies to assess human hazard [J].

Baker, VA .

TOXICOLOGY IN VITRO, 2001, 15 (4-5) :413-419

[5]

*END DISR TEST ADV, 1998, EPA743R98003

[6] Estrogenic potential of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line [J].

Go, V ;

Garey, J ;

Wolff, MS ;

Pogo, BGT .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1999, 107 (03) :173-177

[7] Tiered screening and testing strategy for xenoestrogens and antiandrogens [J].

Gray, LE .

TOXICOLOGY LETTERS, 1998, 103 :677-680

[8] Xenoendocrine disrupters: laboratory studies on male reproductive effects [J].

Gray, LE .

TOXICOLOGY LETTERS, 1998, 103 :331-335

[9]

HERSHBERGER LG, 1953, P SOC EXP BIOL MED, V83, P175

[10] Immature uterotrophic assay is more sensitive than ovariectomized uterotrophic assay for the detection of estrogenicity of p-nonylphenol in Sprague-Dawley rats [J].

Kang, KS ;

Kim, HS ;

Ryu, DY ;

Che, JH ;

Lee, YS .

TOXICOLOGY LETTERS, 2000, 118 (1-2) :109-115

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