Regulatory RNAs in Bacteria

被引:1195
作者
Waters, Lauren S. [1 ]
Storz, Gisela [1 ]
机构
[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, Bethesda, MD 20892 USA
关键词
SMALL NONCODING RNAS; PROVIDES ACQUIRED-RESISTANCE; SOS-INDUCED TOXIN; MESSENGER-RNA; ESCHERICHIA-COLI; GENE-EXPRESSION; 6S RNA; DEPENDENT REGULATION; PROTEIN-SYNTHESIS; GLMS EXPRESSION;
D O I
10.1016/j.cell.2009.01.043
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bacteria possess numerous and diverse means of gene regulation using RNA molecules, including mRNA leaders that affect expression in cis, small RNAs that bind to proteins or base pair with target RNAs, and CRISPR RNAs that inhibit the uptake of foreign DNA. Although examples of RNA regulators have been known for decades in bacteria, we are only now coming to a full appreciation of their importance and prevalence. Here, we review the known mechanisms and roles of regulatory RNAs, highlight emerging themes, and discuss remaining questions.
引用
收藏
页码:615 / 628
页数:14
相关论文
共 119 条
[1]   Mechanism of RNA silencing by Hfq-binding small RNAs [J].
Aiba, Hiroji .
CURRENT OPINION IN MICROBIOLOGY, 2007, 10 (02) :134-139
[2]   A small, stable RNA induced by oxidative stress: Role as a pleiotropic regulator and antimutator [J].
Altuvia, S ;
WeinsteinFischer, D ;
Zhang, AX ;
Postow, L ;
Storz, G .
CELL, 1997, 90 (01) :43-53
[3]   Identification of bacterial small non-coding RNAs: experimental approaches [J].
Altuvia, Shoshy .
CURRENT OPINION IN MICROBIOLOGY, 2007, 10 (03) :257-261
[4]   Virus population dynamics and acquired virus resistance in natural microbial communities [J].
Andersson, Anders F. ;
Banfield, Jillian F. .
SCIENCE, 2008, 320 (5879) :1047-1050
[5]   CsrB sRNA family: sequestration of RNA-binding regulatory proteins [J].
Babitzke, Paul ;
Romeo, Tony .
CURRENT OPINION IN MICROBIOLOGY, 2007, 10 (02) :156-163
[6]   CRISPR provides acquired resistance against viruses in prokaryotes [J].
Barrangou, Rodolphe ;
Fremaux, Christophe ;
Deveau, Helene ;
Richards, Melissa ;
Boyaval, Patrick ;
Moineau, Sylvain ;
Romero, Dennis A. ;
Horvath, Philippe .
SCIENCE, 2007, 315 (5819) :1709-1712
[7]   The role of small RNAs in quorum sensing [J].
Bejerano-Sagie, Michal ;
Xavier, Karina Bivar .
CURRENT OPINION IN MICROBIOLOGY, 2007, 10 (02) :189-198
[8]   Riboswitches as antibacterial drug targets [J].
Blount, Kenneth F. ;
Breaker, Ronald R. .
NATURE BIOTECHNOLOGY, 2006, 24 (12) :1558-1564
[9]   Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism [J].
Boisset, Sandrine ;
Geissmann, Thomas ;
Huntzinger, Eric ;
Fechter, Pierre ;
Bendridi, Nadia ;
Possedko, Maria ;
Chevalier, Clement ;
Helfer, Anne Catherine ;
Benito, Yvonne ;
Jacquier, Alain ;
Gaspin, Christine ;
Vandenesch, Francois ;
Romby, Pascale .
GENES & DEVELOPMENT, 2007, 21 (11) :1353-1366
[10]   Small RNA Binding to 5′ mRNA Coding Region Inhibits Translational Initiation [J].
Bouvier, Marie ;
Sharma, Cynthia M. ;
Mika, Franziska ;
Nierhaus, Knud H. ;
Vogel, Joerg .
MOLECULAR CELL, 2008, 32 (06) :827-837