A real-time photoacoustic tomography system for small animals

被引：182

作者：

Gamelin, John ^{[1
]}

Maurudis, Anastasios ^{[1
]}

Aguirre, Andres ^{[1
]}

Huang, Fei ^{[1
]}

Guo, Puyun ^{[1
]}

Wang, Lihong V. ^{[2
]}

Zhu, Quing ^{[1
]}

机构：

[1] Univ Connecticut, Dept Elect Engn, Storrs, CT 06269 USA

[2] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

来源：

OPTICS EXPRESS | 2009年 / 17卷 / 13期

关键词：

IN-VIVO;

D O I：

10.1364/OE.17.010489

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A real-time 512-element photoacoustic tomography system for small animal imaging using a ring ultrasound array has been developed. The system, based upon a 5 MHz transducer array formed along a 50 mm circular aperture, achieves sub-200 micron lateral resolution over a 2 cm disk-shaped region. Corresponding elevation resolutions of 0.6 to 2.5 mm over the central volume enable depth-resolved 3D tomographic imaging with linear translation. Using 8:1 electronic multiplexing, imaging at up to 8 frame/sec is demonstrated for both dynamic phantoms and in vivo mouse and brain samples. The real-time, full 2D tomographic capability of the system paves the way for functional photoacoustic tomographic imaging studies in small animals with sub-second time frame. (C) 2009 Optical Society of America

引用

页码：10489 / 10498

页数：10

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