Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa

被引：141

作者：

Yoshikawa, Masayuki ^{[1
]}

Matsuda, Hisashi

Morikawa, Toshio

Xie, Haihui

Nakamura, Seikou

Muraoka, Osamu

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

[2] Kinki Univ, Pharmaceut Res & Technol Inst, Osaka 5778502, Japan

[3] Kinki Univ, Sch Pharm, Osaka 5778502, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 22期

关键词：

Cistanche tubulosa; phenylethanoid oligoglycoside; kankanoside F; kankanoside G; kankanose; vasorelaxant activity;

D O I：

10.1016/j.bmc.2006.07.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The methanolic extract from the dried stems of Cistanche tubulosa (Schrenk) R. Wight was found to show an inhibitory effect on contractions induced by noradrenaline in isolated rat aortic strips. From the extract, new phenylethanoid oligoglycoside constituents, kankanosides F and G, and an acylated oligosugar, kankanose, were isolated together with 14 known compounds. The structures of these new compounds were determined on the basis of their chemical and physicochemical evidence. In addition, principal constituents, kankanoside F, kankanose, echinacoside, acteoside, and cistanoside F, showed vasorelaxant activity, and several structural requirements for the activity were clarified. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7468 / 7475

页数：8

共 19 条

[1]

[Anonymous], ENCY WAKAN YAKU TRAD

[2]

C-13 NMR ANALYSIS OF SYMPLOCOSIN AND (+)-EPIPINORESINOL GLUCOSIDE [J].