Sympathetic pathways and adrenergic innervation of the penis

被引:35
作者
Andersson, KE [1 ]
Hedlund, P
Alm, P
机构
[1] Univ Lund, Dept Clin Pharmacol, Univ Lund Hosp, S-22185 Lund, Sweden
[2] Univ Lund, Dept Pathol, Univ Lund Hosp, S-22185 Lund, Sweden
关键词
noradrenaline; sympathetic nerves; penile erection; penile detumescence; alpha adrenoceptors;
D O I
10.1038/sj.ijir.3900513
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The sympathetic nervous system is important for penile function: it mediates detumescence and may contribute to the maintenance of the penis in a non-erect state. The sympathetic preganglionic neurons are found in the intermediolateral gray matter of the spinal cord. Postganglionic neurons are located to the sympathetic chain ganglia, the inferior mesenteric, hypogastric and pelvic ganglia, and possibly to ganglia near the target organ. Sympathetic fibres can be found in the pelvic, cavernous, and pudendal nerves. Stimulation of the sympathetic pathways to the penis may, however, also produce erection. It has been suggested that the suprasacral vasodilator pathway is a sympathetic cholinergic pathway, operating through cholinergic neurons in the pelvic plexus. In the penis, there is a rich sympathetic, adrenergic innervation of the corpus cavernosum (CC) and the vasculature, and in particular of the helicine arteries. Sympathetic, adrenergic nerves also contain neuropeptide Y. Parasympathetic cholinergic nerves, which mediate CC relaxation and erection, contain not only acetylcholine, but also vasoactive intestinal polypeptide, nitric oxide synthase, and probably other mediators and/or mediator-synthesizing enzymes. Activation of sympathetic adrenergic nerves causes release of noradrenaline, acting on ol-adrenoceptors in the trabecular smooth muscle of the CC and in penile vessels. The role of interactions between different transmitters and mediators, released from nerves or generated locally, in the regulation of contraction and relaxation of CC and penile vessels, needs further study.
引用
收藏
页码:S5 / S12
页数:8
相关论文
共 42 条
[21]  
Langley J N, 1895, J Physiol, V19, P71
[22]   A contribution to the neurophysiology of the urinary bladder in man. [J].
Learmonth, JR .
BRAIN, 1931, 54 :147-176
[23]  
LEVIN RM, 1980, INVEST UROL, V18, P225
[24]   ELECTROSTIMULATION AND PENILE ERECTION [J].
LUE, TF ;
SCHMIDT, RA ;
TANAGHO, EA .
UROLOGIA INTERNATIONALIS, 1985, 40 (01) :60-64
[25]   NEUROANATOMY OF PENILE ERECTION - ITS RELEVANCE TO IATROGENIC IMPOTENCE [J].
LUE, TF ;
ZEINEH, SJ ;
SCHMIDT, RA ;
TANAGHO, EA .
JOURNAL OF UROLOGY, 1984, 131 (02) :273-280
[26]  
Lundberg JM, 1996, PHARMACOL REV, V48, P113
[27]   NORADRENALINE RELEASE IN HUMAN CORPUS CAVERNOSUM AND ITS MODULATION VIA PRESYNAPTIC ALPHA-2-ADRENOCEPTORS [J].
MOLDERINGS, GJ ;
GOTHERT, M ;
VANAHLEN, H ;
PORST, H .
FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1989, 3 (05) :497-504
[28]  
MULLER LR, 1902, DTSCH Z NERVENHEILK, V21, P86
[29]  
Muramatsu I, 1995, PHARM COMMUN, V6, P23
[30]  
Price David T., 1993, Journal of Urology, V149, p285A