CD73-adenosine: a next-generation target in immuno-oncology

被引：114

作者：

Allard, David ^{[1
,2
,3
]}

Allard, Bertrand ^{[1
,2
,3
]}

Gaudreau, Pierre-Olivier ^{[1
,2
,3
]}

Chrobak, Pavel ^{[1
,2
,3
]}

Stagg, John ^{[1
,2
,3
]}

机构：

[1] Ctr Hosp Univ Montreal, Ctr Rech, Montreal, PQ, Canada

[2] Inst Canc Montreal, Montreal, PQ, Canada

[3] Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada

来源：

IMMUNOTHERAPY | 2016年 / 8卷 / 02期

关键词：

adenosine; adenosine receptors; anti-tumor immunity; CD73; immune checkpoint; HUMAN BREAST-CANCER; CHRONIC LYMPHOCYTIC-LEUKEMIA; SUPPRESSES TUMOR-GROWTH; REGULATORY T-CELLS; EXTRACELLULAR ADENOSINE; ECTO-5'-NUCLEOTIDASE CD73; OVARIAN-CANCER; CLINICAL-SIGNIFICANCE; PROGNOSTIC BIOMARKER; ANTITUMOR-ACTIVITY;

D O I：

10.2217/imt.15.106

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Cancer immunotherapy has entered in a new era with the development of first-generation immune checkpoint inhibitors targeting the PD1/PD-L1 and CTLA-4 pathways. In this context, considerable research effort is being deployed to find the next generation of cancer immunotherapeutics. The CD73-adenosine axis constitutes one of the most promising pathways in immuno-oncology. We and others have demonstrated the immunosuppressive role of CD73-adenosine in cancer and established proof-of-concept that the targeted blockade of CD73 or adenosine receptors could effectively promote anti-tumor immunity and enhance the activity of first-generation immune checkpoint blockers. With Phase I clinical trials now underway evaluating anti-CD73 or anti-A2A therapies in cancer patients, we here discuss the fundamental, preclinical and clinical findings related to the role of the CD73-adenosinergic pathway in tumor immunity.

引用

收藏

页码：145 / 163

页数：19

相关论文

共 164 条

[91]

High expression and activity of ecto-5'-nucleotidase/CD73 in the male murine reproductive tract [J].

Martin-Satue, Mireia ;

Lavoie, Elise G. ;

Fausther, Michel ;

Lecka, Joanna ;

Aliagas, Elisabet ;

Kukulski, Filip ;

Sevigny, Jean .

HISTOCHEMISTRY AND CELL BIOLOGY, 2010, 133 (06) :659-668

[92]

Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth [J].

Mediavilla-Varela, Melanie ;

Luddy, Kimberly ;

Noyes, David ;

Khalil, Farah K. ;

Neuger, Anthony M. ;

Soliman, Hatem ;

Antonia, Scott J. .

CANCER BIOLOGY & THERAPY, 2013, 14 (09) :860-868

[93]

CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis [J].

Mills, Jeffrey H. ;

Thompson, Linda F. ;

Mueller, Cynthia ;

Waickman, Adam T. ;

Jalkanen, Sirpa ;

Niemela, Jussi ;

Airas, Laura ;

Bynoe, Margaret S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (27) :9325-9330

[94]

Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis [J].

Mills, Jeffrey H. ;

Alabanza, Leah M. ;

Mahamed, Deeqa A. ;

Bynoe, Margaret S. .

JOURNAL OF NEUROINFLAMMATION, 2012, 9

[95]

Human brain endothelial cells are responsive to adenosine receptor activation [J].

Mills, Jeffrey H. ;

Alabanza, Leah ;

Weksler, Babette B. ;

Couraud, Pierre-Olivier ;

Romero, Ignacio A. ;

Bynoe, Margaret S. .

PURINERGIC SIGNALLING, 2011, 7 (02) :265-273

[96]

Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor [J].

Mittal, Deepak ;

Young, Arabella ;

Stannard, Kimberley ;

Yong, Michelle ;

Teng, Michele W. L. ;

Allard, Bertrand ;

Stagg, John ;

Smyth, Mark J. .

CANCER RESEARCH, 2014, 74 (14) :3652-3658

[97]

Expression of Adenosine Receptor Subclasses in Malignant and Adjacent Normal Human Prostate Tissues [J].

Mousavi, Samira ;

Panjehpour, Mojtaba ;

Izadpanahi, Mohammad Hossein ;

Aghaei, Mahmoud .

PROSTATE, 2015, 75 (07) :735-747

[98]

Transfer of the glycosylphosphatidylinositol-anchored 5'-nucleotidase CD73 from adiposomes into rat adipocytes stimulates lipid synthesis [J].

Mueller, G. ;

Jung, C. ;

Wied, S. ;

Biemer-Daub, G. ;

Frick, W. .

BRITISH JOURNAL OF PHARMACOLOGY, 2010, 160 (04) :878-891

[99]

Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma [J].

Nielsen, TO ;

Hsu, FD ;

Jensen, K ;

Cheang, M ;

Karaca, G ;

Hu, ZY ;

Hernandez-Boussard, T ;

Livasy, C ;

Cowan, D ;

Dressler, L ;

Akslen, LA ;

Ragaz, J ;

Gown, AM ;

Gilks, CB ;

van de Rijn, MV ;

Perou, CM .

CLINICAL CANCER RESEARCH, 2004, 10 (16) :5367-5374

[100]

IFN-β regulates CD73 and adenosine expression at the blood-brain barrier [J].

Niemela, Jussi ;

Ifergan, Igal ;

Yegutkin, Gennady G. ;

Jalkanen, Sirpa ;

Prat, Alexander ;

Airas, Laura .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (10) :2718-2726

← 5 6 7 8 9 10 11 12 13 14 →