Immunohistochemical localization of macrophage migration inhibitory factor (MIF) in tanycytes, subcommissural organ and choroid plexus in the rat brain

被引：24

作者：

Nishibori, M ^{[1
]}

Nakaya, N ^{[1
]}

Mori, S ^{[1
]}

Saeki, K ^{[1
]}

机构：

[1] OKAYAMA UNIV,SCH HLTH SCI,OKAYAMA 700,JAPAN

来源：

BRAIN RESEARCH | 1997年 / 758卷 / 1-2期

关键词：

macrophage migration inhibitory factor; tanycyte; ependyma; choroid plexus; subcommissural organ;

D O I：

10.1016/S0006-8993(97)00342-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the immunohistochemical localization of the macrophage migration inhibitory factor (MIF) in the rat brain. in addition to epithelial ependymal cells lining the ventricular wall, tanycytes in the basomedial hypothalamus were heavily immunostained. The immunoreactive processes of tanycytes made contacts to sinusoidal capillaries and reached the pial surface forming an immune-positive structure at the floor of the hypothalamus. Other immunoreactive cells contained the subcommissural organ in the roof of the third ventricle and the epithelial lamina of the choroid plexus. The localization of MIF in cells which have contact with cerebrospinal fluid and blood vessels suggests that MIF might play a role as a humoral factor in the brain.

引用

页码：259 / 262

页数：4

共 27 条

[1] An essential regulatory role for macrophage migration inhibitory factor in T-cell activation [J].