Isolation of an anti-hepatotoxic principle from the juice of Ecballium elaterium

被引：43

作者：

Agil, A ^{[1
]}

Miró, M

Jimenez, J

Aneiros, J

Caracuel, MD

García-Granados, A

Navarro, MC

机构：

[1] Univ Granada, Sch Med, Dept Pharmacol, E-18071 Granada, Spain

[2] Univ Granada, Sch Med, Inst Biotechnol, E-18071 Granada, Spain

[3] Univ Granada, Sch Pharm, Dept Pharmacol, E-18071 Granada, Spain

[4] Univ Granada, Sch Med, Dept Anat Pathol, E-18071 Granada, Spain

[5] Univ Granada, Sch Sci, Dept Organ Chem, E-18071 Granada, Spain

来源：

PLANTA MEDICA | 1999年 / 65卷 / 07期

关键词：

D O I：

10.1055/s-2006-960847

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The antihepatotoxic activity of elaterium (dried juice of the fruits of Ecballium elacterium, Cucurbitaceae) and cucurbitacin B (isolated from the juice) was studied against CCl4-induced hepatotoxicity. Pre- and posttreatment with elaterium and cucurbitacin B reduced CCl4-induced hepatotoxicity, as shown by the reduction in the anormally increased sGPT levels. Posttreatment caused a significant reduction in the degree of steatosis observed in the control group, treated only with CCl4. In conclusion, elaterium and cucurbitacin B had preventive and curative effects against CCl4-induced hepatotoxicity.

引用

页码：673 / 675

页数：3

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