学术探索
学术期刊
新闻热点
数据分析
智能评审

Elevated serum uric acid levels in metabolic syndrome: an active component or an innocent bystander?

被引：228
作者：
Tsouli, Sofia G.
Liberopoulos, Evangelos N.
Mikhailidis, Dimitri P.
Athyros, Vasihos G.
Elisaf, Moses S. [1 ]
机构：
[1] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece
[2] Univ London, Dept Clin Biochem, Vasc Dis Prevent Clin,Royal Free & Univ Coll, Royal Free Hosp,Med Sch, London NW3 2QG, England
[3] Aristotle Univ Thessaloniki, Hipocrat Hosp, Atherosclerosis Unit, Thessaloniki 54642, Greece
来源：
METABOLISM-CLINICAL AND EXPERIMENTAL | 2006年 / 55卷 / 10期
关键词：
D O I：
10.1016/j.metabol.2006.05.013
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Elevated serum uric acid (SUA) levels are commonly seen in patients with the metabolic syndrome (MetS). Several mechanisms, both direct and indirect, connect the increased SUA levels with the established diagnostic criteria of MetS. It is possible that the increased cardiovascular disease risk associated with the MetS is partially attributed to elevated circulating SUA concentration. Several drugs used in the treatment of MetS may alter SUA levels. Thus, lifestyle measures together with the judicious selection of drugs for the treatment of hypertension, dyslipidemia, and insulin resistance associated with MetS may result in a reduction of SUA levels and possibly cardiovascular disease risk. This review summarizes the pathophysiologic association between SUA and MetS and focuses on the prevention of hyperuricemia and its cardiovascular consequences. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：1293 / 1301
页数：9
相关论文
共 175 条
[51]   RELATIONSHIP BETWEEN RESISTANCE TO INSULIN-MEDIATED GLUCOSE-UPTAKE, URINARY URIC-ACID CLEARANCE, AND PLASMA URIC-ACID CONCENTRATION [J].
FACCHINI, F ;
CHEN, YDI ;
HOLLENBECK, CB ;
REAVEN, GM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 266 (21) :3008-3011
[52]   ETHANOL-INDUCED HYPERURICEMIA - EVIDENCE FOR INCREASED URATE PRODUCTION BY ACTIVATION OF ADENINE-NUCLEOTIDE TURNOVER [J].
FALLER, J ;
FOX, IH .
NEW ENGLAND JOURNAL OF MEDICINE, 1982, 307 (26) :1598-1602
[53]   Sevum uric acid and cardiovascular mortality - The NHANES I epidemiologic follow-up study, 1971-1992 [J].
Fang, J ;
Alderman, MH .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (18) :2404-2410
[54]   Allopurinol improves endothelial dysfunction in chronic heart failure [J].
Farquharson, CA ;
Butler, R ;
Hill, A ;
Belch, JJF ;
Struthers, AD .
CIRCULATION, 2002, 106 (02) :221-226
[55]   A DNA POLYMORPHISM OF AN APOPROTEIN GENE ASSOCIATES WITH THE HYPERTRIGLYCERIDEMIA OF PRIMARY GOUT [J].
FERNS, GAA ;
LANHAM, J ;
DIEPPE, P ;
GALTON, DJ .
HUMAN GENETICS, 1988, 78 (01) :55-59
[56]   A review of the metabolic effects of sibutramine [J].
Filippatos, TD ;
Kiortsis, DN ;
Liberopoulos, EN ;
Mikhailidis, DP ;
Elisaf, MS .
CURRENT MEDICAL RESEARCH AND OPINION, 2005, 21 (03) :457-466
[57]   Effect of orlistat, micronised fenofibrate and their combination on metabolic parameters in overweight and obese patients with the metabolic syndrome: the FenOrli study [J].
Filippatos, TD ;
Kiortsis, DN ;
Liberopoulos, EN ;
Georgoula, M ;
Mikhailidis, DP ;
Elisaf, MS .
CURRENT MEDICAL RESEARCH AND OPINION, 2005, 21 (12) :1997-2006
[58]   METABOLIC BASIS FOR DISORDERS OF PURINE NUCLEOTIDE DEGRADATION [J].
FOX, IH .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1981, 30 (06) :616-634
[59]   HYPERURICEMIA AND HYPERTRIGLYCERIDEMIA - METABOLIC BASIS FOR THE ASSOCIATION [J].
FOX, IH ;
JOHN, D ;
DEBRUYNE, S ;
DWOSH, I ;
MARLISS, EB .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1985, 34 (08) :741-746
[60]   Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program (SHEP) [J].
Franse, LV ;
Pahor, M ;
Di Bari, M ;
Shorr, RI ;
Wan, JY ;
Somes, GW ;
Applegate, WB .
JOURNAL OF HYPERTENSION, 2000, 18 (08) :1149-1154
12345678910