Alzheimer's Disease: From Pathology to Therapeutic Approaches

被引：529

作者：

Jakob-Roetne, Roland ^{[1
]}

Jacobsen, Helmut ^{[2
]}

机构：

[1] F Hoffmann La Roche & Cie AG, Med Chem, CH-4070 Basel, Switzerland

[2] F Hoffmann La Roche & Cie AG, CNS Preclin Res, CH-4070 Basel, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 17期

关键词：

Alzheimer's disease; amyloids; drug development; pathology; secretases; AMYLOID-BETA-PROTEIN; GAMMA-SECRETASE INHIBITOR; MEDIAL TEMPORAL-LOBE; BRAIN A-BETA; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GROWTH-FACTOR-I; PRECURSOR PROTEIN; ALPHA-SECRETASE; CEREBROSPINAL-FLUID; P-COMPONENT;

D O I：

10.1002/anie.200802808

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Research on senile dementia and Alzheimer's disease covers an extremely broad range of scientific activities. At the recent international meeting of the Alzheimer's Association (ICAD 2008, Chicago) more than 2200 individual scientific contributions were presented. The aim of this Review is to give an overview of the field and to outline its main areas, starting from behavioral abnormalities and visible pathological findings and then focusing on the molecular details of the pathology. The "amyloid hypothesis" of Alzheimer's disease is given particular attention, since the majority of the ongoing therapeutic approaches are based on its theoretical framework. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3030 / 3059

页数：30

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